Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cdc42p functions at the docking stage of yeast vacuole membrane fusion.

The EMBO journal - 15 Oct 2001

Müller O, Johnson D I, Mayer A

Abstract excerpt

Membrane fusion reactions have been considered to be primarily regulated by Rab GTPases. In the model system of homotypic vacuole fusion in the yeast Saccharomyces cerevisiae, we show that Cdc42p, a member of the Rho family of GTPases, has a direct role in membrane fusion. Genetic evidence suggested a relationship between Cdc42p and Vtc1p/Nrf1p, a central part of the vacuolar membrane fusion machinery. Vacuoles...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
Share to Chelating Agents
Share to Egtazic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanosine 5'-O-(3-Thiotriphosphate)

Share to Membrane Fusion

Share to rab GTP-Binding Proteins

Share to SNARE Proteins

Share to Vacuoles

Source

Open in PubMed Open full text

Identifiers

PMID: 11598009
DOI: 10.1093/emboj/20.20.5657
PMCID: PMC125663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdc42p functions at the docking stage of yeast vacuole membrane fusion.PMID 11598009Read ↗

Rho1p and Cdc42p act after Ypt7p to regulate vacuole docking.Semantic proximity Read ↗

Remodeling of organelle-bound actin is required for yeast vacuole fusion.Semantic proximity Read ↗

The GTPase Ypt7p of Saccharomyces cerevisiae is required on both partner vacuoles for the homotypic fusion step of vacuole inheritance.Semantic proximity Read ↗

Docking of yeast vacuoles is catalyzed by the Ras-like GTPase Ypt7p after symmetric priming by Sec18p (NSF).Semantic proximity Read ↗

Separate membrane targeting and anchoring domains function in the localization of the S. cerevisiae Cdc24p guanine nucleotide exchange factor.Semantic proximity Read ↗

Intrinsic tethering activity of endosomal Rab proteins.Semantic proximity Read ↗

Cdc42p GDP/GTP cycling is necessary for efficient cell fusion during yeast mating.Semantic proximity Read ↗

Cdc42 GTPase regulates ESCRTs in nuclear envelope sealing and ER remodeling.Semantic proximity Read ↗

Cdc42 regulates multiple membrane traffic events in fission yeast.Semantic proximity Read ↗

Guanine nucleotide exchange factors (GEFs) have a critical but not exclusive role in organelle localization of Rab GTPases.Semantic proximity Read ↗

Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud.Semantic proximity Read ↗

Sequential action of two GTPases to promote vacuole docking and fusion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.