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Article

Docking of yeast vacuoles is catalyzed by the Ras-like GTPase Ypt7p after symmetric priming by Sec18p (NSF).

The Journal of cell biology - 27 Jan 1997

Mayer A, Wickner W

Abstract excerpt

Vacuole inheritance in yeast involves the formation of tubular and vesicular "segregation structures" which migrate into the bud and fuse there to establish the daughter cell vacuole. Vacuole fusion has been reconstituted in vitro and may be used as a model for an NSF-dependent reaction of priming, docking, and fusion. We have developed biochemical and microscopic assays for the docking step of in vitro vacuole...

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Identifiers

PMID: 9015302
DOI: 10.1083/jcb.136.2.307
PMCID: PMC2134819

Genes

NSF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Docking of yeast vacuoles is catalyzed by the Ras-like GTPase Ypt7p after symmetric priming by Sec18p (NSF).PMID 9015302Read ↗

The docking of primed vacuoles can be reversibly arrested by excess Sec17p (alpha-SNAP).Semantic proximity Read ↗

Remodeling of organelle-bound actin is required for yeast vacuole fusion.Semantic proximity Read ↗

Sequential action of two GTPases to promote vacuole docking and fusion.Semantic proximity Read ↗

LMA1 binds to vacuoles at Sec18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion.Semantic proximity Read ↗

Cdc42p functions at the docking stage of yeast vacuole membrane fusion.Semantic proximity Read ↗

The GTPase Ypt7p of Saccharomyces cerevisiae is required on both partner vacuoles for the homotypic fusion step of vacuole inheritance.Semantic proximity Read ↗

Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites.Semantic proximity Read ↗

New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion.Semantic proximity Read ↗

Rho1p and Cdc42p act after Ypt7p to regulate vacuole docking.Semantic proximity Read ↗

The vacuolar V1/V0-ATPase is involved in the release of the HOPS subunit Vps41 from vacuoles, vacuole fragmentation and fusion.Semantic proximity Read ↗

ATP-independent control of Vac8 palmitoylation by a SNARE subcomplex on yeast vacuoles.Semantic proximity Read ↗

Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae.Semantic proximity Read ↗

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