Article
The intronic G13964C variant in p53 is not a high-risk mutation in familial breast cancer in Australia.
Breast cancer research : BCR - 1 Jan 2001
Marsh A, Spurdle A B, Turner B C, Fereday S, Thorne H, Pupo G M, Mann G J, Hopper J L, Sambrook J F, Chenevix-Trench G
Abstract excerpt
BACKGROUND: Mutations in BRCA1 and BRCA2 account for approximately 50% of breast cancer families with more than four affected cases, whereas exonic mutations in p53, PTEN, CHK2 and ATM may account for a very small proportion. It was recently reported that an intronic variant of p53--G13964C--occurred in three out of 42 (7.1%) 'hereditary' breast cancer patients, but not in any of 171 'sporadic' breast cancer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.