Article
Absence of association with cancer risk and low frequency of alterations at a p53 responsive PIG3 gene polymorphism in breast and lung carcinomas.
Mutation research - 22 Nov 2004
Gorgoulis V G, Liloglou T, Sigala F, Korkolis D, Yannoukakos D, Papalambros E, Asimacopoulos P J, Papavassiliou A G, Kotsinas A
Abstract excerpt
The mechanisms of p53-dependent apoptosis involve a set of genes that possess the ability to modulate oxidative stress. One of them PIG3, is induced by p53 through a microsatellite in its promoter region. This microsatellite was found to acquire its full structure and p53-functional dependence only in Hominoidea (apes and humans) and has been proposed to represent an evolutionary adaptation of tumor suppressor...
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