Article
The progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of breast cancer in Australian women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2002
Spurdle Amanda B, Hopper John L, Chen Xiaoqing, McCredie Margaret R E, Giles Graham G, Venter Deon J, Southey Melissa C, Chenevix-Trench Georgia
Abstract excerpt
An Alu insertion polymorphism of the progesterone receptor (PR) wasreported recently to be associated with a reduced risk of breast cancer, with risks of 0.8- and 0.3-fold associated with the heterozygote and homozygote genotypes, respectively. This intronic variant is considered to be in linkage disequilibrium with an exon 4 hinge region G to T Val660Leu polymorphism. We investigated whether the exon 4 PR...
Topics
- Adult
- Age Factors
- Australia
- Biomarkers, Tumor
- Breast Neoplasms
- Case-Control Studies
- Exons
- Family Health
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype