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Article

CpG hypermethylation of the promoter region inactivates the estrogen receptor-? gene in patients with prostate carcinoma

1 Jan 2001

Abstract excerpt

BACKGROUND: The down-regulation of the estrogen receptor-beta (ERbeta) gene is associated with several malignancies, including prostate carcinoma. The purpose of the current study was to investigate the mechanisms of ERbeta inactivation through the analysis of CpG methylation of the promoter region of ERbeta gene. METHODS: ERbeta protein expression was examined by immunohistochemistry in 23 cases of human...

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Share to Epigenetics and DNA Methylation
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PMID: 11596023
DOI: 10.1002/1097-0142(20011015)92:8<2076::aid-cncr1548>3.0.co;2-a

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