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Article

Inactivation of the human androgen receptor gene is associated with CpG hypermethylation in uterine endometrial cancer.

Molecular carcinogenesis - 1 Oct 2000

Sasaki M, Oh B R, Dharia A, Fujimoto S, Dahiya R

Abstract excerpt

Androgens mediate their effects through the androgen receptor (AR) and have antiproliferative effects on uterine endometrial cells. In this report, we investigated methylation status and the expression of the AR gene in normal endometrium and uterine endometrial cancer (UEC) tissues using methylation-specific polymerase chain reaction (MSP) and immunohistochemical staining. Seventy of 89 cancer samples were AR...

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PMID: 11074602
DOI: 10.1002/1098-2744(200010)29:2<59::aid-mc2>3.0.co;2-6

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