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Article

Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk.

Proceedings of the National Academy of Sciences of the United States of America - 23 Oct 2001

Vollrath D, Feng W, Duncan J L, Yasumura D, D'Cruz P M, Chappelow A, Matthes M T, Kay M A, LaVail M M

Abstract excerpt

The Royal College of Surgeons (RCS) rat is a widely studied animal model of retinal degeneration in which the inability of the retinal pigment epithelium (RPE) to phagocytize shed photoreceptor outer segments leads to a progressive loss of rod and cone photoreceptors. We recently used positional cloning to demonstrate that the gene Mertk likely corresponds to the retinal dystrophy (rdy) locus of the RCS rat. In...

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Share to Adenoviridae
Share to c-Mer Tyrosine Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer, Horizontal

Share to Phagocytosis

Share to Photoreceptor Cells

Share to Pigment Epithelium of Eye

Share to Receptor Protein-Tyrosine Kinases

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Source

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Identifiers

PMID: 11592982
DOI: 10.1073/pnas.221364198
PMCID: PMC60097

Genes

RPE
MERTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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