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Article

An RCS-like retinal dystrophy phenotype in mer knockout mice.

Investigative ophthalmology & visual science - 1 Feb 2003

Duncan Jacque L, LaVail Matthew M, Yasumura Douglas, Matthes Michael T, Yang Haidong, Trautmann Nikolaus, Chappelow Aimee V, Feng Wei, Earp H Shelton, Matsushima Glenn K, Vollrath Douglas

Abstract excerpt

PURPOSE: To determine whether mice that are homozygous for a targeted disruption of the Mer receptor tyrosine kinase gene (mer(kd)) manifest a retinal dystrophy phenotype similar to RCS rats, which carry a mutation in the orthologous gene MERTK: METHODS: Eyes of mer(kd) and C57BL/6 wild-type (WT) mice were examined by light and electron microscopy, whole-eye rhodopsin measurement, and Ganzfeld electroretinography...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12556419
DOI: 10.1167/iovs.02-0438

Genes

ERG
RPE
MERTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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