Article
Multigene lentiviral vectors based on differential splicing and translational control.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Oct 2001
Zhu Y, Feuer G, Day S L, Wrzesinski S, Planelles V
Abstract excerpt
Lentiviral vectors, so far, have been optimized for the expression of a single open reading frame. Certain practical applications of gene therapy will, however, require expression of multiple genes. The goal of this study was to explore the feasibility of directing expression of two marker genes from a lentiviral vector. We designed two types of multigene lentiviral vectors. First, we used a strategy based on the...
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