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Article

Internal initiation of translation in retroviral vectors carrying picornavirus 5' nontranslated regions

1 Sept 1991

Abstract excerpt

Previous work has shown that picornavirus 5' nontranslated regions (NTRs) can initiate internal translation of downstream coding regions both in vitro and in transient in vivo assays. We have used 5' NTR sequences from encephalomyocarditis virus and poliovirus to construct retroviral vectors that are designed to express two proteins from a single mRNA. Inclusion of 5' NTR sequences did not adversely affect vector...

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PMID: 1651417
DOI: 10.1128/jvi.65.9.4985-4990.1991

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