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Article

Contributions of Viral Splice Sites and cis -Regulatory Elements to Lentivirus Vector Function

1 Jul 1999

Abstract excerpt

The mobile transgene constructs of most human immunodeficiency virus (HIV)-based lentivirus vectors currently in use contain viral long terminal repeats, a 5' untranslated region, gag sequences, and env sequences that include the Rev-responsive element (RRE). In this study, we examined the possibility of deleting HIV splice sites and gag and env sequences from an HIV type 1 recombinant vector established in our...

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PMID: 10364378
DOI: 10.1128/jvi.73.7.6171-6176.1999

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