Article
Expression levels of p53 and p73 isoforms in stage I and stage III ovarian cancer.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2008
Marabese Mirko, Marchini Sergio, Marrazzo Eleonora, Mariani Pietro, Cattaneo Dario, Fossati Roldano, Compagnoni Anna, Signorelli Mauro, Moll Ute M, Codegoni A Maria, Broggini Massimo
Abstract excerpt
The p53 gene has been investigated for its role in epithelial ovarian cancer but data collected until now are contradictory. The evidence that p53 belongs with p63 and p73 to a family of transcription factors re-opened interest in this gene family. Here, we used quantitative real time RT-PCR to determine expression levels of TAp53, TAp73 and their N-terminal splice variants in a cohort of 169 ovarian cancer...
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