Article
Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals.
Pharmacogenetics - 1 Aug 1999
Xie H G, Stein C M, Kim R B, Xiao Z S, He N, Zhou H H, Gainer J V, Brown N J, Haines J L, Wood A J
Abstract excerpt
There are ethnic differences in the prevalence and severity of hypertension and asthma and in beta-2 adrenergic receptor (BAR2)-mediated vascular responses. Two common polymorphisms of the human BAR2, Arg16 to Gly and Gln27 to Glu, are associated with alterations in BAR2 response, both in vitro a...
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