Article
Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites.
Structure (London, England : 1993) - 1 Jul 2005
Park Sunghyouk, Isaacson Rivka, Kim Hyoung Tae, Silver Pamela A, Wagner Gerhard
Abstract excerpt
Ufd1 mediates ubiquitin fusion degradation by association with Npl4 and Cdc48/p97. The Ufd1-ubiquitin interaction is essential for transfer of substrates to the proteasome. However, the mechanism and specificity of ubiquitin recognition by Ufd1 are poorly understood due to the lack of detailed structural information. Here, we present the solution structure of yeast Ufd1 N domain and show that it has two distinct...
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