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Article

Variation in alcohol pharmacokinetics as a risk factor for alcohol dependence.

Alcoholism, clinical and experimental research - 1 Sept 2001

Whitfield J B, Zhu G, Duffy D L, Birley A J, Madden P A, Heath A C, Martin N G

Abstract excerpt

BACKGROUND: The significant association between alcohol dehydrogenase (ADH)-2 genotype and alcohol-dependence risk, demonstrated in both Asian and non-Asian populations, suggests a link between the metabolism of alcohol (ethanol) and individual differences in susceptibility to dependence. METHODS: We tested this hypothesis by following up on subjects who took part in the Alcohol Challenge Twin Study conducted in...

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PMID: 11584143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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