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Article

CD8+ T cells recognizing a neuron-restricted antigen injure axons in a model of multiple sclerosis

7 Sept 2023

Abstract excerpt

CD8+ T cells outnumber CD4+ cells in multiple sclerosis (MS) lesions associated with disease progression, but the pathogenic role and antigenic targets of these clonally expanded effectors are unknown. Based on evidence that demyelination is necessary but not sufficient for disease progression in MS, we previously hypothesized that CNS-infiltrating CD8+ T cells specific for neuronal antigens directly drive the...

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PMID: 37676734
DOI: 10.1172/jci162788

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