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Article

Theiler's Virus‐Mediated Autoimmunity

1 Apr 2002

Abstract excerpt

Theiler's murine encephalomyelitis virus (TMEV), a natural mouse pathogen, is a neurotropic picornavirus that induces a chronic, CD4+ T cell-mediated demyelinating disease with a clinical course and histopathology similar to those of chronic-progressive multiple sclerosis. Upon infection, TMEV-specific CD4+ T cells target persistent viral antigens in the CNS and initiate myelin damage. Later in the disease,...

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Identifiers

PMID: 12021081
DOI: 10.1111/j.1749-6632.2002.tb02944.x

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