Article
Use of transgenic mice to study voltage-dependent Ca2+ channels.
Trends in pharmacological sciences - 1 Oct 2001
Muth J N, Varadi G, Schwartz A
Abstract excerpt
During the past decade a great number of genes encoding high- and low-voltage-dependent Ca(2+) channels and their accessory subunits have been cloned. Studies of Ca(2+) channel structure-function relationships and channel regulation using cDNA expression in heterologous expression systems have revealed intricate details of subunit interaction, regulation of channels by protein kinase A (PKA) and protein kinase C...
Topics
- Animals
- Calcium Channels
- Mice
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Phenotype