Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2009

Fuller-Bicer Geraldine A, Varadi Gyula, Koch Sheryl E, Ishii Masakazu, Bodi Ilona, Kadeer Nijiat, Muth James N, Mikala Gabor, Petrashevskaya Natalia N, Jordan Michael A, Zhang Sui-Po, Qin Ning, Flores Christopher M, Isaacsohn Idit, Varadi Maria, Mori Yasuo, Jones W Keith, Schwartz Arnold

Abstract excerpt

Cardiac L-type voltage-dependent Ca(2+) channels are heteromultimeric polypeptide complexes of alpha(1)-, alpha(2)/delta-, and beta-subunits. The alpha(2)/delta-1-subunit possesses a stereoselective, high-affinity binding site for gabapentin, widely used to treat epilepsy and postherpetic neuralgic pain as well as sleep disorders. Mutations in alpha(2)/delta-subunits of voltage-dependent Ca(2+) channels have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amines
Share to Calcium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Channels, L-Type

Share to Electrophysiology

Share to gamma-Aminobutyric Acid

Share to Myocardial Contraction

Share to Myocytes, Cardiac

Source

Open in PubMed Open full text

Identifiers

PMID: 19429829
DOI: 10.1152/ajpheart.00122.2009
PMCID: PMC2711723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit.PMID 19429829Read ↗

Alternative splicing of the Ca2+ channel beta4 subunit confers specificity for gabapentin inhibition of Cav2.1 trafficking.Semantic proximity Read ↗

Calcium channel alpha2delta subunits: differential expression, function, and drug binding.Semantic proximity Read ↗

Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.Semantic proximity Read ↗

Mutations of calcium channel beta subunit genes in mice.Semantic proximity Read ↗

Alpha 2-adrenergic receptor subtypes: subtle mutation of the alpha 2A-adrenergic receptor in vivo by gene targeting strategies reveals the role of this subtype in multiple physiological settings.Semantic proximity Read ↗

Molecular biology of background K channels: insights from K(2P) knockout mice.Semantic proximity Read ↗

Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice.Semantic proximity Read ↗

Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse.Semantic proximity Read ↗

Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.Semantic proximity Read ↗

Pregabalin action at a model synapse: binding to presynaptic calcium channel alpha2-delta subunit reduces neurotransmission in mice.Semantic proximity Read ↗

Neuronal nicotinic receptors: insights gained from gene knockout and knockin mutant mice.Semantic proximity Read ↗

Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.