Article
Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies.
Journal of clinical pharmacology - 1 Oct 2001
Venkatakrishnan K, Schmider J, Harmatz J S, Ehrenberg B L, von Moltke L L, Graf J A, Mertzanis P, Corbett K E, Rodriguez M C, Shader R I, Greenblatt D J
Abstract excerpt
The relative contribution of cytochrome P450 3A (CYP3A) to the oral clearance of amitriptyline in humans has been assessed using a combination of in vitro approaches together with a clinical pharmacokinetic interaction study using the CYP3A-selective inhibitor ketoconazole. Lymphoblast-expressed CYPs were used to study amitriptyline N-demethylation and E-10 hydroxylation in vitro. The relative activity factor...
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