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Article

Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells.

Journal of virology - 1 Nov 2001

Harris R S, Croom-Carter D S, Rickinson A B, Neuberger M S

Abstract excerpt

It has been suggested that Epstein-Barr virus (EBV) might suppress antibody maturation either by facilitating bypass of the germinal center reaction or by inhibiting hypermutation directly. However, by infecting the Burkitt's lymphoma (BL) cell line Ramos, which hypermutates constitutively and can be considered a transformed analogue of a germinal center B cell, with EBV as well as by transfecting it with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11581418
DOI: 10.1128/JVI.75.21.10488-10492.2001
PMCID: PMC114624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells.PMID 11581418Read ↗

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Deregulated c-myc gene expression and persistence of EBV are not sufficient to maintain the malignant phenotype in Burkitt's lymphoma x B-lymphoblastoid hybrid cells.Semantic proximity Read ↗

Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes.Semantic proximity Read ↗

T cells can induce somatic mutation in B cell receptor-engaged BL2 Burkitt's lymphoma cells independently of CD40-CD40 ligand interactions.Semantic proximity Read ↗

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The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells.Semantic proximity Read ↗

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