Article
Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2005
Souza Tatyana A, Stollar B David, Sullivan John L, Luzuriaga Katherine, Thorley-Lawson David A
Abstract excerpt
Epstein-Barr virus (EBV) establishes a lifelong persistent infection within peripheral blood B cells with the surface phenotype of memory cells. To date there is no proof that these cells have the genotype of true germinal-center-derived memory B cells. It is critical to understand the relative contribution of viral mimicry versus antigen signaling to the production of these cells because EBV encodes proteins...
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