Article
S100B proteins that lack one or both cysteine residues can induce inflammatory responses in astrocytes and microglia.
Neurochemistry international - 1 Jan 2000
Koppal T, Lam A G, Guo L, Van Eldik L J
Abstract excerpt
The astrocytic protein S100B stimulates neurite outgrowth and neuronal survival during CNS development. S100B can also stimulate glial activation, leading to induction of pro-inflammatory molecules like interleukin-1 beta (IL-1 beta) and inducible nitric oxide synthase (iNOS). Although it is known that S100B's neurotrophic activity requires a disulfide-linked dimeric form of the protein, the structural features...
Topics
- Animals
- Astrocytes
- Calcium-Binding Proteins
- Cells, Cultured
- Enzyme Induction
- Inflammation
- Interleukin-1
- Microglia
- Mutation
- Nerve Growth Factors
- Nitric Oxide Synthase