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Article

S100B proteins that lack one or both cysteine residues can induce inflammatory responses in astrocytes and microglia.

Neurochemistry international - 1 Jan 2000

Koppal T, Lam A G, Guo L, Van Eldik L J

Abstract excerpt

The astrocytic protein S100B stimulates neurite outgrowth and neuronal survival during CNS development. S100B can also stimulate glial activation, leading to induction of pro-inflammatory molecules like interleukin-1 beta (IL-1 beta) and inducible nitric oxide synthase (iNOS). Although it is known that S100B's neurotrophic activity requires a disulfide-linked dimeric form of the protein, the structural features...

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PMID: 11578775
DOI: 10.1016/s0197-0186(01)00047-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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