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Article

Oxidation regulates the inflammatory properties of the murine S100 protein S100A8.

The Journal of biological chemistry - 26 Mar 1999

Harrison C A, Raftery M J, Walsh J, Alewood P, Iismaa S E, Thliveris S, Geczy C L

Abstract excerpt

The myeloid cell-derived calcium-binding murine protein, S100A8, is secreted to act as a chemotactic factor at picomolar concentrations, stimulating recruitment of myeloid cells to inflammatory sites. S100A8 may be exposed to oxygen metabolites, particularly hypochlorite, the major oxidant generated by activated neutrophils at inflammatory sites. Here we show that hypochlorite oxidizes the single Cys residue...

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PMID: 10085090
DOI: 10.1074/jbc.274.13.8561

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SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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