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The human hookworm pathogen Necator americanus induces apoptosis in T lymphocytes

1 Jan 2000

Abstract excerpt

In the present study, we demonstrate that Jurkat T cells undergo apoptosis when cocultured with the human hook-worm Necator americanus. Pro-apoptotic activity was dose-dependent and readily detectable in hookworm secretions. This pro-apoptotic effect appears to be specific to cells of T lineage since the monocytic cell line, THP-1, the erythroleukaemic cell line, K562, and the basophil cell line, KU812, were...

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PMID: 10607288
DOI: 10.1046/j.1365-3024.2000.00271.x

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