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Quantitative analysis of UV photolesions suggests that cyclobutane pyrimidine dimers produced in mouse skin by UVB are more mutagenic than those produced by UVC.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology - 18 Apr 2018

Ikehata Hironobu, Mori Toshio, Douki Thierry, Cadet Jean, Yamamoto Masayuki

Abstract excerpt

The amount of photolesions produced in DNA after exposure to physiological doses of ultraviolet radiation (UVR) can be estimated with high sensitivity and at low cost through an immunological assay, ELISA, which, however, provides only a relative estimate that cannot be used for comparisons between different photolesions such as cyclobutane pyrimidine dimer (CPD) and pyrimidine(6-4)pyrimidone photoproduct (64PP)...

Topics

Animals
Cattle
Cyclobutanes
DNA
DNA Damage
Enzyme-Linked Immunosorbent Assay
Mice
Mice, Transgenic
Mutagens
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pyrimidine Dimers

Skin

Ultraviolet Rays

Source

Identifiers

PMID: 29464256
DOI: 10.1039/c7pp00348j

Genes

CPD

Provenance

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