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Giant cell glioblastoma is associated with altered aurora b expression and concomitant p53 mutation.

Journal of neuropathology and experimental neurology - 1 Jun 2010

Temme Achim, Geiger Kathrin D, Wiedemuth Ralf, Conseur Katharina, Pietsch Torsten, Felsberg Jörg, Reifenberger Guido, Tatsuka Masaaki, Hagel Christian, Westphal Manfred, Berger Hilmar, Simon Matthias, Weller Michael, Schackert Gabriele

Abstract excerpt

Giant cell glioblastoma (gcGB), a subtype of GB, is characterized by the presence of numerous multinucleated giant cells. The prognosis for gcGB is poor, but it may have a better clinical outcome compared with classic GB. The molecular alterations that lead to the multinucleated cell phenotype of gcGB have not been elucidated. Giant cell GB has a higher frequency of the tumor suppressor protein p53 mutations than...

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PMID: 20467329
DOI: 10.1097/NEN.0b013e3181e4c06e

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AURKB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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