Article
Tumor necrosis factor-alpha gene polymorphisms in children with multiple sclerosis.
Neuropediatrics - 1 Aug 2001
Anlar B, Alikaşifoglu M, Köse G, Güven A, Gürer Y, Yakut A
Abstract excerpt
Tumor necrosis factor-alpha (TNF-alpha) is a cytokine implicated in the pathogenesis of infectious and autoimmune disorders including multiple sclerosis (MS). Childhood-onset MS presents some clinical and laboratory features differing from adult disease. We studied TNF-alpha - 238 G-->A and - 308 G-->A polymorphisms in 24 patients with childhood-onset MS using PCR-RFLP and compared them with healthy control...
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