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Article

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

29 Jul 2019

Abstract excerpt

Abstract Autoreactivity to myeloperoxidase (MPO) causes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with rapidly progressive glomerulonephritis. Here, we show that a Staphylococcus aureus peptide, homologous to an immunodominant MPO T-cell epitope (MPO409–428), can induce anti-MPO autoimmunity. The peptide (6PGD391–410) is part of a plasmid-encoded 6-phosphogluconate dehydrogenase...

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Share to Antifungal resistance and susceptibility
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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PMID: 31358739
DOI: 10.1038/s41467-019-11255-0

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