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Article

How BCG Led to the Discovery of Immunostimulatory DNA

31 Mar 1999

Abstract excerpt

The concept of immunostimulatory DNA was borne in a long series of studies on BCG-mediated tumor resistance. DNA purified from BCG inhibited the growth of various syngeneic animal tumors, augmented NK cell activity and induced IFN-alpha/beta and -gamma from mouse spleen cells and human PBL. Extending the lines of study, we found two biologically remarkable facts that (i) DNAs from invertebrates, but not from...

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PMID: 10808252
DOI: 10.7883/yoken.52.1

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