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Article

NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2001

Shi Q, Gross K W, Sigmund C D

Abstract excerpt

We previously reported that the promoter proximal portion of the mouse renin enhancer contains a binding site for NF-Y (Ea) that overlaps with a positive regulatory element (Eb). In the context of the renin enhancer, NF-Y acts to oppose enhancer activity. We tested the hypothesis that NF-Y acts as a negative regulator by physically blocking the binding of transcription factors to element-b (Eb). Increasing the...

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Identifiers

PMID: 11566900
DOI: 10.1161/01.hyp.38.3.332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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