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Article

Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2010

Nassiri Marjan, Liu Ju, Kulak Stephen, Uwiera Richard R E, Aird William C, Ballermann Barbara J, Jahroudi Nadia

Abstract excerpt

OBJECTIVE: To determine the role of repressors in cell type and organ-specific activation of von Willebrand factor (VWF) promoter sequences -487 to 247 in vivo. METHODS AND RESULTS: Activation patterns of wild-type and mutant VWF promoters (sequences -487 to 247) containing mutations in repressors nuclear factor-I (NFI)- and nuclear factor Y (NFY)-binding sites were analyzed in transgenic mice. Mutation of the...

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Source

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Identifiers

PMID: 20431063
DOI: 10.1161/ATVBAHA.110.206680
PMCID: PMC3653838

Genes

VWF
NFIB
NFIX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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