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Article

The NFY transcription factor functions as a repressor and activator of the von Willebrand factor promoter

1 Apr 2002

Abstract excerpt

Human von Willebrand factor (VWF) gene sequences -487 to +247 function as an endothelial-specific promoter in vitro. Analysis of the activation mechanism of the VWF promoter has resulted in the identification of a number of cis-acting elements and trans-acting factors that regulate its activity. The GATA and Ets transcription factors were shown to function as activators of transcription, whereas NF1 and Oct1 were...

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PMID: 11895773
DOI: 10.1182/blood.v99.7.2408

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