Article
Tumor necrosis factor-alpha activates NFkappaB to inhibit renin transcription by targeting cAMP-responsive element.
The Journal of biological chemistry - 9 Jan 2004
Todorov Vladimir T, Völkl Simon, Müller Markus, Bohla Alexander, Klar Jürgen, Kunz-Schughart Leoni A, Hehlgans Thomas, Kurtz Armin
Abstract excerpt
Tumor necrosis factor-alpha (TNFalpha) is known to inhibit renin gene expression in juxtaglomerular cells, which are the main source of renin in vivo. In the present study we aimed to characterize the intracellular mechanisms of TNFalpha signaling to renin gene in the mouse juxtaglomerular cell line As4.1. TNFalpha was found to activate NFkappaB, which is one of the principal intracellular mediators of TNFalpha...
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