Article
Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension.
The Journal of clinical investigation - 1 Aug 1998
Asico L D, Ladines C, Fuchs S, Accili D, Carey R M, Semeraro C, Pocchiari F, Felder R A, Eisner G M, Jose P A
Abstract excerpt
Since dopamine receptors are important in the regulation of renal and cardiovascular function, we studied the cardiovascular consequences of the disruption of the D3 receptor, a member of the family of D2-like receptors, expressed in renal proximal tubules and juxtaglomerular cells. Systolic and...
Topics
- Angiotensin I
- Angiotensin Receptor Antagonists
- Animals
- Blood Pressure
- Disease Models, Animal
- Diuresis
- Genotype
- Hypertension
- Juxtaglomerular Apparatus
- Kidney Tubules, Proximal
- Mice
- Mice, Knockout
- Natriuresis
- Receptors, Angiotensin