Article
Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension.
The Journal of clinical investigation - 1 Aug 1998
Asico L D, Ladines C, Fuchs S, Accili D, Carey R M, Semeraro C, Pocchiari F, Felder R A, Eisner G M, Jose P A
Abstract excerpt
Since dopamine receptors are important in the regulation of renal and cardiovascular function, we studied the cardiovascular consequences of the disruption of the D3 receptor, a member of the family of D2-like receptors, expressed in renal proximal tubules and juxtaglomerular cells. Systolic and diastolic blood pressures were higher (approximately 20 mmHg) in heterozygous and homozygous than in wild-type mice. An...
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