Article
Learning impairments and motor dysfunctions in adult Lhx5-deficient mice displaying hippocampal disorganization.
Physiology & behavior - 1 Aug 2001
Paylor R, Zhao Y, Libbey M, Westphal H, Crawley J N
Abstract excerpt
Lhx5 is a member of the LIM homeobox gene family that regulates development of the nervous system. Adult mice generated with a mutation in Lhx5 were found to display absent or disorganized hippocampal neuroanatomy. The pyramidal cell layer in Ammon's horn and the granule cell layer in the dentate gyrus were absent or poorly defined in the hippocampus of adult Lhx5 knockout mice. Behavioral phenotyping of Lhx5...
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