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Sensitivity and tolerance to ethanol-induced incoordination and hypothermia in HAFT and LAFT mice.

Pharmacology, biochemistry, and behavior - 1 Sept 2001

Rustay N R, Boehm S L, Schafer G L, Browman K E, Erwin V G, Crabbe J C

Abstract excerpt

Acute functional tolerance (AFT) manifests as rapid adaptation during a single ethanol exposure, leading to a decrease in the behavioral response to ethanol. In order to investigate the genetic and environmental components of the development of AFT, mice were selectively bred in replicate from HS/Ibg mice. High (HAFT) and low (LAFT) acute functional tolerance selected lines were bred to differ in the rate of...

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PMID: 11566154
DOI: 10.1016/s0091-3057(01)00595-0

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