Article
c-Myc and Sp1/3 are required for transactivation of hamster telomerase catalytic subunit gene promoter.
International journal of oncology - 1 Oct 2001
Park N H, Guo W, Kim H R, Kang M K, Park N H
Abstract excerpt
The hamster and human TERT promoters share common critical protein binding sites, such as the GC-box or E-box, which is known to be a binding site for Sp1/Sp3 transcriptional factors and c-Myc, respectively. Our previous data demonstrated that Sp1/Sp3 synergistically transactivate the hamster TERT (hamTERT) promoter. In this study, we determined the role of c-Myc in the regulation of hamTERT, and analyzed the...
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