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Activation of Telomerase RNA Gene Promoter Activity by NF-Y, Sp1, and the Retinoblastoma Protein and Repression by Sp3

1 Jan 2000

Abstract excerpt

Expression of the human telomerase RNA component gene, hTERC is essential for telomerase activity. The hTERC gene is expressed during embryogenesis and then downregulated during normal development, leaving most adult somatic cells devoid of hTERC expression. During oncogenesis, however, hTERC is re-expressed consequently contributing to the unrestricted proliferative capacity of many human cancers. Thus the...

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Share to RNA Interference and Gene Delivery
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Share to Telomeres, Telomerase, and Senescence

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PMID: 11228546
DOI: 10.1038/sj.neo.7900114

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Related research

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Research trail→

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Activation of Telomerase RNA Gene Promoter Activity by NF-Y, Sp1, and the Retinoblastoma Protein and Repression by Sp3PMID 11228546Read ↗

The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes.Semantic proximity Read ↗

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Sp1 and Sp3 transactivate the RET proto-oncogene promoter.Semantic proximity Read ↗

Identification of a novel transcription factor binding element involved in the regulation by differentiation of the human telomerase (hTERT) promoter.Semantic proximity Read ↗

Human Telomerase Reverse Transcriptase (hTERT) Transcription Requires Sp1/Sp3 Binding to the Promoter and a Permissive Chromatin EnvironmentSemantic proximity Read ↗

The human telomerase RNA gene (hTERC) is regulated during carcinogenesis but is not dependent on DNA methylationSemantic proximity Read ↗

Genome-wide identification of expression quantitative trait loci for human telomerase.Semantic proximity Read ↗

Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells.Semantic proximity Read ↗

c-Myc and Sp1/3 are required for transactivation of hamster telomerase catalytic subunit gene promoter.Semantic proximity Read ↗

C-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (hTERT) promoter.Semantic proximity Read ↗

Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells.Semantic proximity Read ↗

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