Article
Effects of mutations within two hydrophilic regions of the bovine papillomavirus type 1 E1 DNA-binding domain on E1-E2 interaction.
The Journal of general virology - 1 Oct 2001
Woytek Kelly J, Rangasamy Dhandapani, Bazaldua-Hernandez Cynthia, West Mike, Wilson Van G
Abstract excerpt
The interaction between papillomavirus E1 and E2 proteins is essential for viral genome replication. Using both in vivo and in vitro assays to evaluate the regions of the two proteins necessary for the E1-E2 interaction, three independent interactions were identified for bovine papillomavirus E1: the N terminus of E1 (E1N, residues 1-311) interacts with the E2 transactivation domain (E2TAD) and the E2 DNA-binding...
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