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Article

Binding of bovine papillomavirus E1 to the origin is not sufficient for DNA replication.

Virology - 1 Mar 1993

Spalholz B A, McBride A A, Sarafi T, Quintero J

Abstract excerpt

Replication of the bovine papillomavirus (BPV-1) DNA requires both the viral E1 and E2 gene products. The minimal origin of replication, which resides in a 60-basepair fragment centered on the unique HpaI site of the BPV-1 genome, can be bound by the E1 protein and is flanked by E2 binding sites. The integrity of the region surrounding the unique HpaI restriction enzyme site is important for E1 binding and DNA...

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Identifiers

PMID: 8382395
DOI: 10.1006/viro.1993.1116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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