Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens.

Antimicrobial agents and chemotherapy - 17 Aug 2023

Gingras Hélène, Peillard-Fiorente Flora, Godin Chantal, Patron Kevin, Leprohon Philippe, Ouellette Marc

Abstract excerpt

Two strains of Streptococcus pneumoniae, one expressing the methyltransferase Erm(B) and the other negative for erm(B), were selected for solithromycin resistance in vitro either with direct drug selection or with chemical mutagenesis followed by drug selection. We obtained a series of mutants that we characterized by next-generation sequencing. We found mutations in various ribosomal proteins (L3, L4, L22, L32,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macrolides

Share to Microbial Sensitivity Tests

Share to Mutation

Share to Streptococcus pneumoniae

Source

Open in PubMed Open full text

Identifiers

PMID: 37409958
DOI: 10.1128/aac.00395-23
PMCID: PMC10433811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens.PMID 37409958Read ↗

Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance.Semantic proximity Read ↗

Macrolide Resistance in Streptococcus pneumoniae.Semantic proximity Read ↗

Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America.Semantic proximity Read ↗

Inactivation of a purine biosynthesis repressor promotes ribosome synthesis to overcome antibiotic stress.Semantic proximity Read ↗

Pneumococcal resistance to macrolides, lincosamides, ketolides, and streptogramin B agents: molecular mechanisms and resistance phenotypes.Semantic proximity Read ↗

Novel mechanisms of macrolide resistance revealed by in vitro selection and genome analysis in Mycoplasma pneumoniaeSemantic proximity Read ↗

High-level telithromycin resistance in laboratory-generated mutants of Streptococcus pneumoniae.Semantic proximity Read ↗

Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila.Semantic proximity Read ↗

Inducible Mega-Mediated Macrolide Resistance Confers Heteroresistance in Streptococcus pneumoniaeSemantic proximity Read ↗

A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporterSemantic proximity Read ↗

Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA.Semantic proximity Read ↗

Structural studies on ribosomes of differentially macrolide-resistant Staphylococcus aureus strainsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.