Article
Genotyping the Prop-1 mutation in Ames dwarf mice.
Mechanisms of ageing and development - 1 Oct 2001
Dollé M E, Snyder W K, Vijg J
Abstract excerpt
The Ames dwarf mouse phenotype is based on a homozygous single gene mutation in the Prop-1 gene that markedly extends life span. Since its discovery, interest in breeding these mice as a model to study retardation of aging has increased dramatically. However, the homozygous Prop-1 mutants are infertile, which necessitates breeding heterozygotes. Heterozygotes cannot be distinguished from the wildtype, while the...
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