Article
Array-based expression analysis of mouse liver genes: effect of age and of the longevity mutant Prop1df.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Feb 2001
Dozmorov I, Bartke A, Miller R A
Abstract excerpt
Ames dwarf mice, homozygous for the df allele at the Prop1 locus, live 40% to 70% longer than nonmutant siblings and represent the first single-gene mutant that extends life span in a mammal. To gain insight into the basis for the longevity of the Ames dwarf mouse, we measured liver mRNA levels for 265 genes in a group of 11 df/df mice, (three to four mice per age group), at ages 5, 13, and 22 months, and in 13...
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