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Article

4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia.

Brain pathology (Zurich, Switzerland) - 1 Oct 2001

McKracken E, Graham D I, Nilsen M, Stewart J, Nicoll J A, Horsburgh K

Abstract excerpt

Oxidative stress and lipid peroxidation may contribute to the pathology of neurodegenerative disorders such as Alzheimer's disease (AD) and cerebral ischemia. 4-Hydroxynonenal (4-HNE) is a toxic by-product of lipid peroxidation, and immunoreactivity to 4-HNE has been used to examine lipid peroxidation in the pathogenesis of AD and ischemia. This study sought to determine 1) if there are cellular alterations in...

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Identifiers

PMID: 11556686
DOI: 10.1111/j.1750-3639.2001.tb00409.x
PMCID: PMC8098262

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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