Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endocytic pathway alterations in human hippocampus after global ischemia and the influence of APOE genotype.

The American journal of pathology - 1 Jan 2003

McColl Barry W, Graham David I, Weir Christopher J, White Fiona, Horsburgh Karen

Abstract excerpt

Apolipoprotein epsilon4 (apoE, protein; APOE, gene) allele is the most important genetic risk factor for development of Alzheimer's disease and is also associated with poor outcome after brain injury. Although the mechanisms underlying this susceptibility are currently unknown, recent experimental evidence suggests that APOE genotype may influence activity in the endocytic pathway of neurons. This study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Brain Ischemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endocytosis

Share to Hippocampus

Share to Neurofibrillary Tangles

Share to Neuroglia

Share to Temporal Lobe

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12507910
DOI: 10.1016/S0002-9440(10)63818-7
PMCID: PMC1851134

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endocytic pathway alterations in human hippocampus after global ischemia and the influence of APOE genotype.PMID 12507910Read ↗

Influence of apolipoprotein E genotype on neuronal damage and apoE immunoreactivity in human hippocampus following global ischemia.Semantic proximity Read ↗

Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia.Semantic proximity Read ↗

4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia.Semantic proximity Read ↗

Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge.Semantic proximity Read ↗

Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia.Semantic proximity Read ↗

Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion.Semantic proximity Read ↗

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.Semantic proximity Read ↗

Human Apolipoprotein E4 Worsens Acute Axonal Pathology but Not Amyloid-β Immunoreactivity After Traumatic Brain Injury in 3×TG-AD MiceSemantic proximity Read ↗

Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders.Semantic proximity Read ↗

A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice.Semantic proximity Read ↗

The role of ApoE on fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditionsSemantic proximity Read ↗

Alzheimer-associated presenilin 2 gene is dysregulated in rat medial temporal lobe cortex after complete brain ischemia due to cardiac arrestSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.