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Article

Biallelic inactivation of NF1 in a sporadic plexiform neurofibroma.

Genes, chromosomes & cancer - 1 Sept 2012

Beert Eline, Brems Hilde, Renard Marleen, Ferreiro Julio Finalet, Melotte Cindy, Thoelen Reinhilde, De Wever Ivo, Sciot Raf, Legius Eric, Debiec-Rychter Maria

Abstract excerpt

Plexiform neurofibromas are a major cause of morbidity in individuals with neurofibromatosis type 1 (NF1). Sporadically, these tumors appear as an isolated feature without other signs of NF1. A role for the NF1 gene in solitary plexiform neurofibromas has never been described. In this study, we report a 13-year-old boy who was diagnosed with a plexiform neurofibroma, without other NF1 diagnostic criteria. The...

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Identifiers

PMID: 22585738
DOI: 10.1002/gcc.21969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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