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Article

Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma.

Genome research - 1 Mar 2013

Gutmann David H, McLellan Michael D, Hussain Ibrahim, Wallis John W, Fulton Lucinda L, Fulton Robert S, Magrini Vincent, Demeter Ryan, Wylie Todd, Kandoth Cyriac, Leonard Jeffrey R, Guha Abhijit, Miller Christopher A, Ding Li, Mardis Elaine R

Abstract excerpt

Low-grade brain tumors (pilocytic astrocytomas) arising in the neurofibromatosis type 1 (NF1) inherited cancer predisposition syndrome are hypothesized to result from a combination of germline and acquired somatic NF1 tumor suppressor gene mutations. However, genetically engineered mice (GEM) in which mono-allelic germline Nf1 gene loss is coupled with bi-allelic somatic (glial progenitor cell) Nf1 gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23222849
DOI: 10.1101/gr.142604.112
PMCID: PMC3589532

Genes

GEM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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