Article
Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1.
Neurology - 25 Nov 2003
Gutmann D H, James C D, Poyhonen M, Louis D N, Ferner R, Guha A, Hariharan S, Viskochil D, Perry A
Abstract excerpt
BACKGROUND: Fifteen to 20% of children with neurofibromatosis type 1 (NF1) develop low-grade astrocytomas. Although brain tumors are less common in teenagers and adults with NF1, recent studies have suggested that patients with NF1 are at a significantly increased risk of developing astrocytomas. OBJECTIVE: S: To investigate the genetic basis for astrocytoma development in patients with NF1 beyond the first...
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